Are any you ladies actually annoyed about what he said?
I'm not actually annoyed by O'Neill unfunny moment, however, how people respond to someone who does take offense is typical of a lack of effort to imagine why she took offense. Through the ages and even today, women have struggled to be taken seriously. For instance, if they wanted to continue studying, they had to fight for it. In professions that were usually exclusively male, they have had to endure the condescending and lame jokes, like O'Neill's. Actually, in a lot of workplaces where women are a minority, those jokes are still prevalent. Some women are the target of that kind of joke just walking in the street.
And when women object, they are told they are overreacting, to get a sense of humour, to get a life, and that they need to get laid. The jokes and the jokers are not malicious, but they show a lack of appropriateness, and the lingering opinion that it's alright to make "just a joke". After all, men wouldn't take offense if the tables were turned, right? No, not straight white males, no.
Replace women for non-whites, or gays, or jews. They get the same "don't be a spoilsport, I don't mean any harm" jokes. To illustrate: institutions like the police complain they fail in recruiting blacks, or Asians, or gays. Wasn't there a recent report in the UK about institutional racism? I wouldn't be surprised if some minority groups are the butt of "just jokes" in the police, or the army. And equally I wouldn't be surprised if someone complained, he or she is told to lighten up, and by the bosses too. Nobody bothers to wonder why the target is upset or insulted. It means their experiences are not taken seriously. It's condescending. You would have to have a very thick skin to want to work there. Same for women: a female friend of mine is a surgeon, and in 2016 she also needs a thick skin to deflect all the jokes from her male colleagues about women. And as long as those jokes are viewed as acceptable, or not worth getting worked up about, there is no equality.
I'm not preaching political correctness, where everybody tiptoes around language and humour. But a little more awareness of historical struggles and of how people still suffer from discrimination wouldn't go amiss.